Dr. Kerri Taylor
Doctorate of Philosophy in chemistry, The University of Akron 2011-2016
Research Adviser: Dr. Wiley J. Youngs
- Synthesized imidazolium salts (IS) for use as potential antitumor pharmaceuticals and UTI exfoliants. Evaluated structure activity relationship of substituted N,N’-bis(arylmethyl)imidazolium and benzimidazolium salts tested against non-small cell lung cancer (NSCLC) cell lines NCI-H460, NCI-H1975, HCC827, and NCI-A549 cells. Enhancement of the imidazolium salts’ anti-proliferative activities were achieved through substituent variations in the different series of imidazolium salts.
- Gained experience with the synthesis of silver carbene complexes for use in anti-microbial studies and helped to optimize the synthetic procedure of SCC1.
Master of Science in chemistry, The University of Kentucky 2008-2011
Research Adviser: Dr. John E. Anthony
- Synthesized c-fused anthradithiophene quinones for the intended use as acceptor material for organic photovoltaic devices. Enhancement of these compounds was conducted through tetrafunctionalization of silylethynyl groups. Studied trends of crystal packing with synthesized derivatives. Synthesis of acenequinones was accomplished through integration of different heterocycles.
- Research focus was on integrated areas of organic chemistry and materials science.
Bachelors of Arts in chemistry, Miami University 2004-2008
My research projects involve the synthesis and characterization of new compounds with the application of medicinal chemistry, including anti-cancer and antimicrobial agents. The chemistry of organic heterocycles (particularly imidazole and benzimidazole rings) is investigated to develop prospective anti-cancer therapeutics. One major of Dr. Taylor’s is to create compounds that can act as a dual pharmaceutical system, by incorporating imidazolium salts with an ancillary ligand to form a fluorescent hybrid salt. Application of this project would have the ancillary ligand serve as the fluorescent indicator on the anti-cancer drug, and potentially allow visibility to show the site of malignant tissue.
Projects in the Taylor lab will be collaborative in nature as the synthesized compounds will be studied by modern characterization techniques and examined by key biological assays. In addition to exploring the chemistry of main group elements, areas of interest also include metal based drugs.
Dr. Shelton Taylor has published 4 peer-reviewed scientific articles and chapter:
- Shelton, K.L., DeBord, M.A., Wagers, P.O., Panzner, M.J., Southerland, M.R., Taraboletti, A.A., Robishaw, N.K., Jackson, D.J., Tessier, C.A., Shriver, L.P., Youngs, W.J. Synthesis, Anti-proliferative activity and Toxicity of C4(C5)-substituted N,N’-bis(arylmethyl)imidazolium salts against select non-small cell lung cancer cell lines. Tetrahedron, Manuscript Accepted.
- Wagers, P.O., Tiemann, K.M., Shelton, K.L., Kofron, W.G., Panzner, M.J., Wooley, K.L., Youngs, W.J. and Hunstad, D.A. Imidazolium salts as small-molecule urinary bladder exfoliants in a murine model. Antimicrob. Agents Chemother. 2015, 59, 5494-5502. DOI 10.1128/AAC.00881-15.
- Wright, B.D., Deblock, M.C., Wagers, P.O., Duah, E., Robishaw, N.K., Shelton, K.L., Southerland, M.R., DeBord, M.A., Kersten, K.M., McDonald, L.J., Stiel, J.A., Panzner, M.J., Tessier, C.A., Paruchuri, S., Youngs, W.J. Anti-tumor activity of lipophilic imidazolium salts on select NSCLC cell lines. Med. Chem. Res. 2015, 24, 2838-2861. DOI 10.1007/s00044-015-1330-z.
- Wagers, P.O., Shelton, K.L., Panzner, M.J., Tessier, C.A. and Youngs, W.J. (2014) Synthesis and Medicinal Properties of Silver–NHC Complexes and Imidazolium Salts, in N-Heterocyclic Carbenes: Effective Tools for Organometallic Synthesis (ed S. P. Nolan), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. DOI: 10.1002/9783527671229.ch06.
Dr. Kerri Shelton Taylor, assistant professor of Organic Chemistry at Columbus State University, obtained her Ph.D. in Chemistry from The University of Akron and MS in Chemistry from The University of Kentucky.
She has a broad knowledge and varied skill set in the field of synthetic medicinal chemistry and material science, which enables her to be a significant contributor in the scientific community. Her exposure to multiple areas of chemistry, particularly organic and material science, has led to strengthened synthetic skills and increased her chemical knowledge as an academic researcher.
She has presented at 8 local and national scientific conferences and received the Dr. Henry and Jean Stevens Graduate Fellowship and Outstanding Teaching Assistant Award at The University of Akron. Dr. Taylor has also been a member of the American Chemical Society (ACS).